Skeeter News: Fantastic Cure for West Nile Disease?


Alex Wierbinski's picture

By Alex Wierbinski - Posted on 29 March 2018

 

Skeeter News

Fantastic Cure for West Nile Disease?

Researchers develop a novel RNA-based therapy to target West Nile virus,
Yale University, March 29, 2018.

"...a new RNA therapy, delivered through the nose, to treat mice infected with West Nile Virus. The innovative approach reduced the virus in the brain, allowing the immune system to destroy the virus and develop long-term protection against West Nile Virus disease."

"...focused on a small "interfering" RNA molecule developed in her lab. The RNA acts against multiple mosquito-borne flaviviruses. To direct the RNA to infected cells, they packaged it in a peptide derived from the rabies virus, which is able to enter nerve cells. The final step was to the deliver the therapy through the nose where it could bypass natural barriers protecting the brain."

"...treated mice had a 90% survival rate a few days after infection compared to mice treated with placebo. Significantly, noted the researchers, in the surviving mice, the immune system cleared the virus throughout the body, and also enabled long-term protection against future exposure."

"...it should be an effective strategy for people."

 

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