High Altitude Medicine: Half Acetazolamide Dosage Sufficient


Alex Wierbinski's picture

By Alex Wierbinski - Posted on 12 March 2019

MOUNTAIN SAFETY

 

Himalayan Altitude Sickness Warning - Indian Army
Himalayan Altitude Sickness Warning - Indian Army, Wiki by Sistak
Wiki by Sistak

 

Mountain Sickness Medicine

Cutting the standard dose of medication for acute mountain sickness in half does not reduce its effectiveness,
Elsevier, March 11, 2019.

MAIN POINTS

Altitude Sickness
“...10 to 25 percent of trekkers and climbers ascending above 2,500 meters experience AMS, increasing to 50 to 85 percent in individuals ascending above 4,500 to 5,500 meters, especially when the ascent is rapid.”

Acetazolamide
“...acetazolamide is the standard agent of choice for prophylaxis against altitude illness.”

Side Effects
“...the medication also has problematic side effects, especially at high doses.”

“...paresthesia, altered sensation of taste, frequent urination, headache, nausea, and rash have been found to be more common at higher doses and can lead to safety concerns at high altitudes.”

“...set out to find the lowest possible dose to prevent AMS with the least number and severity of side effects.”

Half Dose Sufficient
"We found that half the recommended prophylactic dose, 62.5 mg twice daily, was just as effective in preventing AMS."

But...
Side Effects Continued
"Our study did not support our secondary hypothesis that there would be fewer, less severe side effects with the reduced dose, as previous studies had led us to predict."

Nonetheless…
“This finding confirmed the reduced dose was as effective as the standard dose.”

 

Practical

Altitude Sickness, Training, and Safety as Part of Hiking Plan Prep

 

Dealing with and Avoiding Bad High Altitude (& other bad) Starts

 

Practically Scientific…
Mountain Madness is Real: Are You Crazy?

 

 

The Science

High Altitude Medicine: Improving Prediction of Altitude Problems

 

Andean Mountain Strength & Sickness

 

Acetaminophen for preventing acute mountain sickness

 

Generally

Altitude Sickness
Wiki

 

Spring is Coming. Is your first aid kit ready?

Safety First!
Cayenne’s First Aid Kit for High Sierra Backpackers

Are You?

 

TOP

 

 

Health & Fitness News

 

March 2018 Trail News

 

 

 

 

More
News From Nature

 

Climate Destruction News

 

Trees

Bee News

Bear News

Spider Forum

Bird News

Small Mammals

Frogs and Reptiles

Butterfly News

 

Health and Fitness

Mountain Safety

Mosquito News

Female Trail

High Sierra History

 

Astro-Phys, Space, & Science News

High Sierra Geology News

Fish, Oceans, & Water News

Anthropocene

 

All High Sierra News

 

 

TOP

 

mountain sickness, altitude sickness, acetazolamide, prevention, reduced, half, dosage, effective, research, information, training

 

Powered by Drupal, an open source content management system

Latest News: RSS FEED

Syndicate content

Support Tahoe to Whitney

The Tahoe to Whitney Trail Guide and Magazine are walked, written, funded, and supported by my efforts, with the help of kindred spirits and my sister.

We offer valuable Trail Guide, Skills, Weather, News and Analysis.

My goal is to get you out to see your natural and social potential. Help me keep this unique resource accessible and expanding towards its potential. We've a lot of miles to cover ahead...

I NEED HELP!
If you feel these efforts are valuable, I'm cordially inviting you to support them, here:

 

 

I am currently working towards publishing the completed guide between Tahoe & Yosemite as an e-book, while converting this "blog" to a fine magazine format. You will like the results! Help Tahoe to Whitney reach its potential!

 

Why Support Tahoe to Whitney?
Mission Statement